Mast Cell Activation Syndrome

Mast Cells

Important mediators of inflammation
Play a role in both innate and adaptive immune responses
Mast cells are found in connective tissue throughout the body in almost every organ
When mast cells are activated by immune reactions, they degranulate and release various inflammatory mediators (like histamine) into the extracellular space

Mast Cells Have Many Effects on Immune Response

Mast Cell Activation and CIRS

Many people that suffer from chronic inflammatory response syndrome also have excessive mast cell activation
When mast cells are activated and degranulate, they release histamine (as well as several other immune modulating substances)
Excess histamine can cause numerous symptoms

Manifestations of High Histamine

Metabolically Directed Approach to Mast Cell Activation

Fix what is wrong!
Mast Cell Activation is a Symptom of a Hyper-stimulated Immune System
Certain Metabolic Imbalances Underlie Mast Cell Activation and Need Addressing
Environmental Issues are Frequently Causative

Metabolically Directed Approach to Mast Cell Activation

Treat underlying metabolic and hormonal imbalances
Identify and reduce stressors (like bio-toxin illness)
Diet should be free of excess sugars and toxic oils (canola, soy…)
Low histamine diet

Metabolic Imbalances Associated with MCAS

Parasympathetic Imbalance
Tissue Acidosis (Anaerobic Imbalance)
Systemic Alkalosis
Excess Cortotropin Releasing Hormone
Lipopolysaccharide (LPS) exposure – from dysbiosis
Estrogen Dominance
Hypothyroidism

Causes of Mast Cell Activation Syndrome

Estrogen Dominance is a Common Contributor to MCAS

Estrogen Dominance
Increases Parasympathetic Tone
Increases Anaerobic Imbalance
Impairs thyroid function

Chronic Stress as a Contributor to MCAS

Chronic Stress raises cortisol
Elevated cortisol increases anaerobic metabolism
Elevated cortisol tends to increase systemic alkalinity
Elevated cortisol contributes to reverse T3 syndome and a functional hypothyroidism

Minimize/Avoid High Histamine Foods

Pickles, mayonnaise, sauerkraut, vinegar, dried fruits, yeast, food additives, tomatoes, seeds, nuts, chocolate, cocoa, processed meats, canned vegetables, egg whites, spices, beer, wine, champagne, shellfish, tofu cheese, mushrooms, aged cheeses, spinach

Metabolically Directed Treatment for MCAS

Fix what is wrong!
Improve diet – avoid excess carbohydrates, sugars and PUFAs, High Histamine Foods
Address Environmental/Stealth Organism Issues (CIRS)
Address Sex and Adrenal Cortex Imbalances
Address Thryoid Imbalances
Address Metabolic Imbalances

Foods with anti-histamine effects

Apples – rich in quercitin
Carrots – rich in vitamin A
Watercress – inhibits histamine release
Broccoli – H2 receptor antagonist
Ginger – H2 receptor antagonist
Thyme – anaphylaxis inhibitor
Fennel – antioxidant, antihistamine, anti-inflammatory
Tumeric – stabilizes mast cells, inhibits histamine release

Potentially Helpful Supplements for MCAS

Complex P – to reduce excess parasympathetic activity
Proton Plus, Magnesium Chloride – to reduce systemic alkalinity
DIM, Calcium-D-Glucurate to reduce excess estrogen activity
Immunosynbiotic to repair dysbiosis and decrease lipopolysaccharides
Other metabolically directed supplementation as needed

Drugs for MCAS

H1 – Histamine receptor antagonists (Diphenhydramine, Hydroxyzine, cetirizine, fexofenadine)
H2 – Histamine receptor antagonists (ranitidine, famotidine)
Cyproheptadine,is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties
Mast Cell Stabilizers (NasalCrom, GastroCrom)
Leukotriene inhibitors (Singulair, montelukast)
Ketotifen is a benzocycloheptathiophene derivative that has powerful antihistamine and mast cell stabilizing effects cyproheptadine and azatadine

To learn more about MD Wellness contact us today by giving us a call at (732) 268-7663, emailing us at [email protected] or by requesting an appointment online.

1670 ROUTE 34 N. 3R FLOOR SUITE 3C WALL • NJ 07727

+1 732 268-7663

1670 ROUTE 34 N. 3R FLOOR SUITE 3C WALL • NJ 07727

+1 732 268-7663

Mast Cell Activation Syndrome

Mast Cells

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